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Title: Expression of importin-α isoforms in human nasal mucosa: Implication for adaptation of avian influenza A viruses to human host
Authors: Khwansiri Ninpan
Ornpreya Suptawiwat
Chompunuch Boonarkart
Peerayuht Phuangphung
Sakda Sathirareuangchai
Mongkol Uiprasertkul
Prasert Auewarakul
Mahidol University
Keywords: Immunology and Microbiology
Issue Date: 4-Jun-2016
Citation: Virology Journal. Vol.13, No.1 (2016)
Abstract: © 2016 The Author(s). Background: Transportation into the host cell nucleus is crucial for replication and transcription of influenza virus. The classical nuclear import is regulated by specific cellular factor, importin-α. Seven isoforms of importin-α have been identified in human. The preference of importin-α3 of avian influenza virus and -α7 isoform of human strains during replication in human cells was previously identified. In addition, both avian and human influenza viruses were shown to use importin-α1 isoform for their replication. Finding: The mRNA levels of importin-α1, -α3, and -α7 isoforms in human respiratory tract was determined by real-time RT-PCR. The results indicate that mRNA level of importin-α7 was significantly higher than that of importin-α1 (p-value < 0.0001) and importin-α3 (p-value < 0.0001) isoforms in human nasal mucosa while importin-α1 was detected as the highest expression importin-α isoform in lung tissues. Conclusions: These results may explain the preference of importin-α7 isoforms in seasonal influenza viruses in human upper respiratory tract and may suggest a selective pressure toward importin-α7 in human respiratory tract infection of an avian virus.
ISSN: 1743422X
Appears in Collections:Scopus 2016-2017

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