Please use this identifier to cite or link to this item:
|Title:||Gene models, expression repertoire, and immune response of Plasmodium vivax reticulocyte binding proteins|
Wai Hong Tham
Walter and Eliza Hall Institute of Medical Research
University of Melbourne
|Keywords:||Immunology and Microbiology|
|Citation:||Infection and Immunity. Vol.84, No.3 (2016), 677-685|
|Abstract:||© 2016 Hietanen et al.. Members of the Plasmodium vivax reticulocyte binding protein (PvRBP) family are believed to mediate specific invasion of reticulocytes by P. vivax. In this study, we performed molecular characterization of genes encoding members of this protein family. Through cDNA sequencing, we constructed full-length gene models and verified genes that are protein coding and those that are pseudogenes. We also used quantitative PCR to measure their in vivo transcript abundances in clinical P. vivax isolates. Like genes encoding related invasion ligands of P. falciparum, Pvrbp expression levels vary broadly across different parasite isolates. Through antibody measurements, we found that host immune pressure may be the driving force behind the distinctly high diversity of one of the family members, PvRBP2c. Mild yet significant negative correlation was found between parasitemia and the PvRBP2b antibody level, suggesting that antibodies to the protein may interfere with invasion.|
|Appears in Collections:||Scopus 2016-2017|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.