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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/40831
Title: Differences in liver impairment between adults and children with dengue infection
Authors: Rosario Martínez Vega
Weerapong Phumratanaprapin
Benjaluck Phonrat
Jittima Dhitavat
Maleerat Sutherat
Vorada Choovichian
Mahidol University
Tan Tock Seng Hospital
Keywords: Immunology and Microbiology
Issue Date: 1-May-2016
Citation: American Journal of Tropical Medicine and Hygiene. Vol.94, No.5 (2016), 1073-1079
Abstract: Copyright © 2016 by The American Society of Tropical Medicine and Hygiene. Dengue infection (DI) is a major vector-borne disease in southeast Asia and an important cause of morbidity. The complications such as hepatic impairment are common, and because the physiology of the liver differs between children and adults, the DI-associated liver impairments might be expected to differ as well. This study aims to compare the differences in liver impairment between adults and children with DI. We retrospectively studied 158 adults and 79 children with serologically confirmed DI admitted to the Bangkok Hospital for Tropical Diseases from 2008 to 2012. In total, 93% of adults and 87% of children exhibited abnormal liver enzyme levels during hospitalization. Overall, 76 (42.4%) adults and 16 (20.3%) children had dengue hemorrhagic fever (DHF). Compared with children, adults with dengue fever (DF) presented a significantly higher incidence of liver function impairment (alanine transaminase [ALT] > 2 × upper limit of normal [ULN]) (47.1% versus 25.5%), hepatitis (ALT > 4 × ULN) (29.4% versus 12.8%), and severe hepatitis (aspartate transaminase [AST]/ALT > 10 × ULN) (16.5% versus 4.3%). Children with DHF showed a significantly higher incidence of liver function impairment due to AST derangement than did adults (100% versus 73%). There were no differences in the total bilirubin, albumin, or total protein levels between adults and children. Liver enzymes normalized significantly more slowly in adults, and AST recovery was faster than ALT. In conclusion, liver function impairment was more common among adults than children with DF. As the severity progressed to DHF, liver injury became more common in children.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84966478688&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/40831
ISSN: 00029637
Appears in Collections:Scopus 2016-2017

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