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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/40858
Title: Validation of a monoclonal antibody-based immunofluorescent assay to detect Burkholderia pseudomallei in blood cultures
Authors: Adul Dulsuk
Suporn Paksanont
Adisak Sangchankoom
Peeraya Ekchariyawat
Rungnapa Phunpang
Yaowaruk Jutrakul
Narisara Chantratita
T. Eoin West
Mahidol University
Udon Thani Regional Medical Sciences Center
University of Washington, Seattle
Keywords: Immunology and Microbiology
Issue Date: 1-Jan-2016
Citation: Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.110, No.11 (2016), 670-672
Abstract: © The Author 2016. Background: Identification of Burkholderia pseudomallei, the cause of melioidosis, using routine methods takes several days. Use of a monoclonal antibody-based immunofluorescent assay (IFA) on positive blood cultures may speed diagnosis. Methods: We tested the diagnostic accuracy of the IFA on 545 blood cultures positive for Gram-negative organisms at Udon Thani Hospital, Thailand, between June 2015 and August 2016. Results: Sensitivity of the IFA was 100% and specificity was 99.6%. The median decrease in time to pathogen identification between the IFA result and routine methods was 28 h (IQR 25-51), p < 0.0001. Conclusions: The IFA accurately expedites the diagnosis of melioidosis.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85014381547&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/40858
ISSN: 18783503
00359203
Appears in Collections:Scopus 2016-2017

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