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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/40901
Title: Human T cell responses to Japanese encephalitis virus in health and disease
Authors: Lance Turtle
Tanushka Bali
Gemma Buxton
Savita Chib
Sajesh Chan
Mohammed Soni
Mohammed Hussain
Heather Isenman
Prachi Fadnis
Manjunatha M. Venkataswamy
Vishali Satishkumar
Penny Lewthwaite
Ayako Kurioka
Srinivasa Krishna
M. Veera Shankar
Riyaz Ahmed
Ashia Begum
Vasanthapuram Ravi
Anita Desai
Sutee Yoksan
Stefan Fernandez
Christian B. Willberg
Henrik N. Kloverpris
Christopher Conlon
Paul Klenerman
Vijaya Satchidanandam
Tom Solomon
University of Liverpool
Royal Liverpool and Broadgreen University Hospitals NHS Trust
Indian Institute of Science, Bangalore
Vijayanagar Institute of Medical Sciences
National Institute of Mental Health and Neuro Sciences
National Health Service
University of Oxford
Mahidol University
Armed Forces Research Institute of Medical Sciences, Thailand
Keywords: Immunology and Microbiology
Issue Date: 1-Jan-2016
Citation: Journal of Experimental Medicine. Vol.213, No.7 (2016), 1331-1352
Abstract: © 2016 Turtle et al. Japanese encephalitis (JE) virus (JEV) is an important cause of encephalitis in children of South and Southeast Asia. However, the majority of individuals exposed to JEV only develop mild symptoms associated with long-lasting adaptive immunity. The related flavivirus dengue virus (DENV) cocirculates in many JEV-endemic areas, and clinical data suggest cross-protection between DENV and JEV. To address the role of T cell responses in protection against JEV, we conducted the first full-breadth analysis of the human memory T cell response using a synthetic peptide library. Ex vivo interferon-γ (IFN-γ) responses to JEV in healthy JEV-exposed donors were mostly CD8+and targeted nonstructural (NS) proteins, whereas IFN-γ responses in recovered JE patients were mostly CD4+and targeted structural proteins and the secreted protein NS1. Among patients, a high quality, polyfunctional CD4+T cell response was associated with complete recovery from JE. T cell responses from healthy donors showed a high degree of cross-reactivity to DENV that was less apparent in recovered JE patients despite equal exposure. These data reveal divergent functional CD4+and CD8+T cell responses linked to different clinical outcomes of JEV infection, associated with distinct targeting and broad flavivirus cross-reactivity including epitopes from DENV, West Nile, and Zika virus.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84977658045&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/40901
ISSN: 15409538
00221007
Appears in Collections:Scopus 2016-2017

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