Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/40950
Title: The impact of residual symptoms on relapse and quality of life among Thai depressive patients
Authors: Thanita Hiranyatheb
Daochompu Nakawiro
Tinakon Wongpakaran
Nahathai Wongpakaran
Putipong Bookkamana
Manee Pinyopornpanish
Nattha Saisavoey
Kamonporn Wannarit
Sirina Satthapisit
Sitthinant Tanchakvaranont
Mahidol University
Chiang Mai University
Department of Psychiatry Khon Kaen Hospital
Keywords: Medicine
Issue Date: 12-Dec-2016
Citation: Neuropsychiatric Disease and Treatment. Vol.12, (2016), 3175-3181
Abstract: © 2016 Hiranyatheb et al. Purpose: Residual symptoms of depressive disorder are major predictors of relapse of depression and lower quality of life. This study aims to investigate the prevalence of residual symptoms, relapse rates, and quality of life among patients with depressive disorder. Patients and methods: Data were collected during the Thai Study of Affective Disorder (THAISAD) project. The Hamilton Rating Scale for Depression (HAMD) was used to measure the severity and residual symptoms of depression, and EQ-5D instrument was used to measure the quality of life. Demographic and clinical data at the baseline were described by mean ± standard deviation (SD). Prevalence of residual symptoms of depression was determined and presented as percentage. Regression analysis was utilized to predict relapse and patients’ quality of life at 6 months postbaseline. Results: A total of 224 depressive disorder patients were recruited. Most of the patients (93.3%) had at least one residual symptom, and the most common was anxiety symptoms (76.3%; 95% confidence interval [CI], 0.71–0.82). After 3 months postbaseline, 114 patients (50.9%) were in remission and within 6 months, 44 of them (38.6%) relapsed. Regression analysis showed that residual insomnia symptoms were significantly associated with these relapse cases (odds ratio [OR]=5.290, 95% CI, 1.42–19.76). Regarding quality of life, residual core mood and insomnia significantly predicted the EQ-5D scores at 6 months postbaseline (B =-2.670, 95% CI, -0.181 to -0.027 and B =-3.109, 95% CI, -0.172 to -0.038, respectively). Conclusion: Residual symptoms are common in patients receiving treatment for depressive disorder and were found to be associated with relapses and quality of life. Clinicians need to be aware of these residual symptoms when carrying out follow-up treatment in patients with depressive disorder, so that prompt action can be taken to mitigate the risk of relapse.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85006789742&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/40950
ISSN: 11782021
11766328
Appears in Collections:Scopus 2016-2017

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.