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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/40957
Title: Phenotypic characteristics and comparative proteomics of Staphylococcus aureus strains with different vancomycin-resistance levels
Authors: Auttawit Sirichoat
Aroonlug Lulitanond
Rattiyaporn Kanlaya
Ratree Tavichakorntrakool
Aroonwadee Chanawong
Sujintana Wongthong
Visith Thongboonkerd
Khon Kaen University
Mahidol University
Keywords: Medicine
Issue Date: 1-Dec-2016
Citation: Diagnostic Microbiology and Infectious Disease. Vol.86, No.4 (2016), 340-344
Abstract: © 2016 Elsevier Inc. Reduced vancomycin susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide problem. Unfortunately, its genetic marker and molecular mechanisms remained unknown. This study investigated differential phenotypic characteristic and protein expression profiles among three groups of MRSA isolates, including vancomycin-susceptible S. aureus (VSSA), heterogeneous vancomycin-intermediate S. aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) (n = 7 isolates/group). Phenotypic characteristic revealed significant greater number of isolates with non-spreading colony in VISA as compared to both VSSA and hVISA groups. 2-DE followed by nanoLC-MS/MS analyses revealed increased glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in both hVISA and VISA, whereas 50S ribosomal protein L14 (RplN) and DNA-binding protein II (Hup) were increased only in VISA. The non-spreading colony and GAPDH level of MRSA may be used as the markers for differentiation of VSSA, hVISA and VISA.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84993977928&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/40957
ISSN: 18790070
07328893
Appears in Collections:Scopus 2016-2017

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