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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/41012
Title: Pharmacokinetics of Colistin Following a Single Dose of Intravenous Colistimethate Sodium in Critically Ill Neonates
Authors: Narongsak Nakwan
Siripa Usaha
Kulkanya Chokephaibulkit
Paola Villani
Mario Regazzi
Roberto Imberti
Hat Yai Hospital
Mahidol University
Fondazione IRCCS Policlinico San Matteo
Keywords: Medicine
Issue Date: 1-Nov-2016
Citation: Pediatric Infectious Disease Journal. Vol.35, No.11 (2016), 1211-1214
Abstract: Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. In this study, we sought to evaluate the pharmacokinetics of colistin after intravenous administration of colistimethate sodium (CMS) in the critically ill neonates with Gram-negative bacterial infections. A single intravenous dose of CMS [approximately 150,000 IU/kg, equivalent to 5 mg/kg colistin base activity (CBA)] was administered to 7 critically ill neonates. Mean (±SD) maximum plasma colistin concentration and area under the time-concentration curve from 0 to infinity were 3.0 ± 0.7 μg/mL and 25.3 ± 10.4 μg·h/mL, respectively. Time to maximum concentration, half-life, apparent volume of distribution and clearance were 1.3 ± 0.9 hours, 9.0 ± 6.5 hours, 7.7 ± 9.3 L/kg and 0.6 ± 0.3 L/h/kg, respectively. After a dose regimen of 5 mg/kg CBA every 24 hours, the average concentration expected at steady state is 1.1 ± 0.4 μg/mL. In critically ill neonates, a single intravenous dose of 5 mg CBA/kg (approximately 150,000 IU/kg of CMS) resulted in suboptimal plasma concentrations of colistin. According to our pharmacokinetics data, the dosage of CMS currently used in critically ill neonates is insufficient.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84973375144&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/41012
ISSN: 15320987
08913668
Appears in Collections:Scopus 2016-2017

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