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dc.contributor.authorSu Jin Hongen_US
dc.contributor.authorSoo Heon Parken_US
dc.contributor.authorJeong Seop Moonen_US
dc.contributor.authorWoon Geon Shinen_US
dc.contributor.authorJae Gyu Kimen_US
dc.contributor.authorYong Chan Leeen_US
dc.contributor.authorDong Ho Leeen_US
dc.contributor.authorJae Young Jangen_US
dc.contributor.authorJae J. Kimen_US
dc.contributor.authorHang Lak Leeen_US
dc.contributor.authorSang Woo Leeen_US
dc.contributor.authorYoung Hwangboen_US
dc.contributor.authorJianming Xuen_US
dc.contributor.authorBangmao Wangen_US
dc.contributor.authorZhanxiong Xueen_US
dc.contributor.authorFei Liuen_US
dc.contributor.authorYaozong Yuanen_US
dc.contributor.authorSomchai Leelakusolvongen_US
dc.contributor.authorFrederick Dyen_US
dc.contributor.otherSoonchunhyang University, College of Medicineen_US
dc.contributor.otherThe Catholic University of Korea, College of Medicineen_US
dc.contributor.otherInje University Paik Hospitalen_US
dc.contributor.otherHallym University, College of Medicineen_US
dc.contributor.otherChung-Ang University, College of Medicineen_US
dc.contributor.otherYonsei University College of Medicineen_US
dc.contributor.otherSeoul National University Bundang Hospitalen_US
dc.contributor.otherKyung Hee Universityen_US
dc.contributor.otherSungKyunKwan University, School of Medicineen_US
dc.contributor.otherHanYang University, College of Medicineen_US
dc.contributor.otherKorea University Medical Centeren_US
dc.contributor.otherAnhui Medical Universityen_US
dc.contributor.otherTianjin Medical Universityen_US
dc.contributor.otherWenzhou Medical Universityen_US
dc.contributor.otherTongji Universityen_US
dc.contributor.otherShanghai Jiao Tong Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Santo Tomas Hospitalen_US
dc.identifier.citationGut and Liver. Vol.10, No.6 (2016)en_US
dc.description.abstractBackground/Aims: To investigate the effects of esomeprazole and rebamipide combination therapy on symptomatic improvement in patients with reflux esophagitis. Methods: A total of 501 patients with reflux esophagitis were randomized into one of the following two treatment regimens: 40 mg esomeprazole plus 300 mg rebamipide daily (combination therapy group) or 40 mg esomeprazole daily (monotherapy group). We used a symptom questionnaire that evaluated heartburn, acid regurgitation, and four upper gastrointestinal symptoms. The primary efficacy end point was the mean decrease in the total symptom score. Results: The mean decreases in the total symptom score at 4 weeks were estimated to be -18.1±13.8 in the combination therapy group and -15.1±11.9 in the monotherapy group (p=0.011). Changes in reflux symptoms from baseline after 4 weeks of treatment were -8.4±6.6 in the combination therapy group and -6.8±5.9 in the monotherapy group (p=0.009). Conclusions: Over a 4-week treatment course, esomeprazole and rebamipide combination therapy was more effective in decreasing the symptoms of reflux esophagitis than esomeprazole monotherapy.en_US
dc.rightsMahidol Universityen_US
dc.titleThe benefits of combination therapy with esomeprazole and rebamipide in symptom improvement in reflux esophagitis: An international multicenter studyen_US
Appears in Collections:Scopus 2016-2017

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