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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/41084
Title: Outcome of phlebotomy for treating nonalcoholic fatty liver disease: A systematic review and meta-analysis
Authors: Veeravich Jaruvongvanich
Tanawan Riangwiwat
Anawin Sanguankeo
Sikarin Upala
University of Hawaii at Manoa
King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University
Columbia University, College of Physicians and Surgeons
Mahidol University
Keywords: Medicine
Issue Date: 1-Nov-2016
Citation: Saudi Journal of Gastroenterology. Vol.22, No.6 (2016), 407-414
Abstract: Background/Aims: No medications have been approved for managing nonalcoholic fatty liver disease (NAFLD). Lifestyle intervention is the mainstay for its treatment. Hyperferritinemia, which appears to be associated with the severity of liver injury and insulin resistance, is frequently observed in patients with NAFLD. Patients and Methods: We conducted a systematic review and meta-analysis of the outcomes of four interventional trials regarding the effect of phlebotomy in patients with NAFLD versus the outcomes of NAFLD patients who did not undergo phlebotomy. Primary outcome was the pooled mean difference (MD) of the homeostasis model assessment of insulin resistance (HOMA-IR). The secondary outcomes were the changes in liver enzymes and the lipid profile. Results: Four interventional studies involving 438 participants were included in the meta-analysis. HOMA-IR was lower in patients who underwent phlebotomy, with an MD of 0.84 [95% confidence interval (CI) 0.01 to 1.67, I2 = 72%]. Phlebotomy also significantly reduced the alanine aminotransferase (MD = 10.05, 95% CI 7.19-12.92, I2 = 34%) and triglyceride (MD = 9.89, 95% CI 4.96-14.83, I2 = 22%) levels and increased the high-density cholesterol level (MD = 3.48, 95% CI 2.03-4.92, I2 = 18%). Conclusion: Phlebotomy decreased insulin resistance and liver transaminase levels in patients with NAFLD. In addition, it improved their lipid profile.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85011296325&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/41084
ISSN: 19984049
13193767
Appears in Collections:Scopus 2016-2017

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