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Title: Hepatitis B and C co-infection in HIV patients from the TREAT Asia HIV observational database: Analysis of risk factors and survival
Authors: Marcelo Chen
Wing Wai Wong
Matthew G. Law
Sasisopin Kiertiburanakul
Evy Yunihastuti
Tuti Parwati Merati
Poh Lian Lim
Romanee Chaiwarith
Praphan Phanuphak
Man Po Lee
Nagalingeswaran Kumarasamy
Vonthanak Saphonn
Rossana Ditangco
Benedict L.H. Sim
Kinh Van Nguyen
Sanjay Pujari
Adeeba Kamarulzaman
Fujie Zhang
Thuy Thanh Pham
Jun Yong Choi
Shinichi Oka
Pacharee Kantipong
Mahiran Mustafa
Winai Ratanasuwan
Nicolas Durier
Yi Ming Arthur Chen
Kaohsiung Medical University
Mackay Memorial Hospital Taiwan
National Taiwan University College of Medicine
Veterans General Hospital-Taipei
University of New South Wales (UNSW) Australia
Mahidol University
University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
Universitas Udayana
Tan Tock Seng Hospital
Research Institute for Health Sciences
The HIV Netherlands Australia Thailand Research Collaboration
Queen Elizabeth Hospital Hong Kong
VHS Medical Centre India
University of Health Sciences
Hospital Sungai Buloh
National Hospital for Tropical Diseases
Institute of Infectious Diseases
University of Malaya Medical Centre
Beijing Ditan Hospital
Bach Mai Hospital
Yonsei University College of Medicine
National Center for Global Health and Medicine
Chiangrai Prachanukroh Hospital
Hospital Raja Perempuan Zainab II
amfAR - The Foundation for AIDS Research
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Mar-2016
Citation: PLoS ONE. Vol.11, No.3 (2016)
Abstract: © 2016 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background We assessed the effects of hepatitis B (HBV) or hepatitis C (HCV) co-infection on outcomes of antiretroviral therapy (ART) in HIV-infected patients enrolled in the TREAT Asia HIV Observational Database (TAHOD), a multi-center cohort of HIV-infected patients in the Asia-Pacific region. Methods Patients testing HBs antigen (Ag) or HCV antibody (Ab) positive within enrollment into TAHOD were considered HBV or HCV co-infected. Factors associated with HBV and/orHCV co-infection were assessed by logistic regression models. Factors associated with post-ART HIV immunological response (CD4 change after six months) and virological response (HIV RNA <400 copies/ml after 12 months) were also determined. Survival was assessed by the Kaplan-Meier method and log rank test. Results A total of 7,455 subjects were recruited by December 2012. Of patients tested, 591/5656 (10.4%) were HBsAg positive, 794/5215 (15.2%) were HCVAb positive, and 88/4966 (1.8%) were positive for both markers. In multivariate analysis, HCV co-infection, age, route of HIV infection, baseline CD4 count, baseline HIV RNA, and HIV-1 subtype were associated with immunological recovery. Age, route of HIV infection, baseline CD4 count, baseline HIV RNA, ART regimen, prior ART and HIV-1 subtype, but not HBV or HCV co-infection, affected HIV RNA suppression. Risk factors affecting mortality included HCV co-infection, age, CDC stage, baseline CD4 count, baseline HIV RNA and prior mono/dual ART. Shortest survival was seen in subjects who were both HBV-and HCV-positive. Conclusion In this Asian cohort of HIV-infected patients, HCV co-infection, but not HBV co-infection, was associated with lower CD4 cell recovery after ART and increased mortality.
ISSN: 19326203
Appears in Collections:Scopus 2016-2017

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