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dc.contributor.authorKamonrat Phopinen_US
dc.contributor.authorNujarin Sinthupoomen_US
dc.contributor.authorLertyot Treeratanapiboonen_US
dc.contributor.authorSarun Kunwittayaen_US
dc.contributor.authorSupaluk Prachayasittikulen_US
dc.contributor.authorSomsak Ruchirawaten_US
dc.contributor.authorVirapong Prachayasittikulen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChulabhorn Research Instituteen_US
dc.contributor.otherMinistry of Educationen_US
dc.identifier.citationEXCLI Journal. Vol.15, (2016), 144-152en_US
dc.description.abstract© 2016, Leibniz Research Centre for Working Environment and Human Factors. All right reserved. 8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.en_US
dc.rightsMahidol Universityen_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleAntimalarial and antimicrobial activities of 8-aminoquinoline-uracils metal complexesen_US
Appears in Collections:Scopus 2016-2017

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