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|Title:||Antimalarial and antimicrobial activities of 8-aminoquinoline-uracils metal complexes|
Chulabhorn Research Institute
Ministry of Education
|Keywords:||Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology|
|Citation:||EXCLI Journal. Vol.15, (2016), 144-152|
|Abstract:||© 2016, Leibniz Research Centre for Working Environment and Human Factors. All right reserved. 8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.|
|Appears in Collections:||Scopus 2016-2017|
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