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Title: Psoriasis and risk of incident atrial fibrillation: A systematic review and meta-analysis
Authors: Patompong Ungprasert
Narat Srivali
Wonngarm Kittanamongkolchai
Mayo Clinic
Mahidol University
Keywords: Medicine
Issue Date: 1-Sep-2016
Citation: Indian Journal of Dermatology, Venereology and Leprology. Vol.82, No.5 (2016), 489-497
Abstract: © 2016 Indian Journal of Dermatology, Venereology, and Leprology Published by Wolters Kluwer - Medknow. Background and Objectives: Patients with psoriasis might have a higher risk of developing atrial fibrillation as a result of chronic inflammation. This study aimed to investigate this association by comprehensively reviewing all available evidence. Methods: We conducted a systematic review and meta-analysis of cohort studies that reported relative risk, hazard ratio, incidence ratio or standardized incidence ratio with 95% confidence intervals comparing the risk of incident atrial fibrillation in patients with psoriasis versus participants without psoriasis. Both retrospective and prospective cohort studies were eligible. Pooled risk ratio and 95% confidence intervals were calculated using random-effect, generic inverse variance methods of DerSimonian and Laird. Results: Three retrospective studies with 110,568 cases of psoriasis and 5,352,817 participants without psoriasis were included in this meta-analysis. The pooled risk ratio of subsequent development of atrial fibrillation in patients with psoriasis versus participants without psoriasis was 1.21 (95% confidence interval, 1.14-1.29). The statistical heterogeneity was low with an I2of 29%. Limitations: Coding-based design of the primary studies that had limited accuracy. Conclusions: Our meta-analysis demonstrated a statistically significant increase in the risk of incident atrial fibrillation among patients with psoriasis.
ISSN: 09733922
Appears in Collections:Scopus 2016-2017

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