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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/41232
Title: Rheopathologic Consequence of Plasmodium vivax Rosette Formation
Authors: Rou Zhang
Wenn Chyau Lee
Yee Ling Lau
Letusa Albrecht
Stefanie C.P. Lopes
Fabio T.M. Costa
Rossarin Suwanarusk
Francois Nosten
Brian M. Cooke
Laurent Rénia
Bruce Russell
Yong Loo Lin School of Medicine
Agency for Science, Technology and Research, Singapore
University of Malaya
Universidade Estadual de Campinas
Mahidol University
Nuffield Department of Clinical Medicine
Monash University
University of Otago
Fundacao Oswaldo Cruz
Keywords: Medicine
Issue Date: 10-Aug-2016
Citation: PLoS Neglected Tropical Diseases. Vol.10, No.8 (2016)
Abstract: © 2016 Zhang et al. Malaria parasites dramatically alter the rheological properties of infected red blood cells. In the case of Plasmodium vivax, the parasite rapidly decreases the shear elastic modulus of the invaded RBC, enabling it to avoid splenic clearance. This study highlights correlation between rosette formation and altered membrane deformability of P. vivax-infected erythrocytes, where the rosette-forming infected erythrocytes are significantly more rigid than their non-rosetting counterparts. The adhesion of normocytes to the PvIRBC is strong (mean binding force of 440pN) resulting in stable rosette formation even under high physiological shear flow stress. Rosetting may contribute to the sequestration of PvIRBC schizonts in the host microvasculature or spleen.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84988736266&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/41232
ISSN: 19352735
19352727
Appears in Collections:Scopus 2016-2017

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