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Title: Smoking and projected cardiovascular risk in an HIV-positive Asian regional cohort
Authors: T. C. Do
D. Boettiger
M. Law
S. Pujari
F. Zhang
R. Chaiwarith
S. Kiertiburanakul
M. P. Lee
R. Ditangco
W. W. Wong
K. V. Nguyen
T. P. Merati
T. T. Pham
A. Kamarulzaman
S. Oka
E. Yunihastuti
N. Kumarasamy
P. Kantipong
J. Y. Choi
O. T. Ng
N. Durier
K. Ruxrungtham
The HIV Netherlands Australia Thailand Research Collaboration
University of New South Wales (UNSW) Australia
Institute of Infectious Diseases
Beijing Ditan Hospital
Research Institute for Health Sciences
Mahidol University
Queen Elizabeth Hospital Hong Kong
Veterans General Hospital-Taipei
National Hospital for Tropical Diseases
Universitas Udayana
Bach Mai Hospital
University of Malaya Medical Centre
National Center for Global Health and Medicine
University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
VHS Medical Centre India
Chiangrai Prachanukroh Hospital
Yonsei University College of Medicine
Tan Tock Seng Hospital
Foundation for AIDS Research
Chulalongkorn University
Keywords: Medicine
Issue Date: 1-Aug-2016
Citation: HIV Medicine. Vol.17, No.7 (2016), 542-549
Abstract: © 2016 British HIV Association Objectives: The aim of the study was to assess the prevalence and characteristics associated with current smoking in an Asian HIV-positive cohort, to calculate the predictive risks of cardiovascular disease (CVD), coronary heart disease (CHD) and myocardial infarction (MI), and to identify the impact that simulated interventions may have. Methods: Logistic regression analysis was used to distinguish associated current smoking characteristics. Five-year predictive risks of CVD, CHD and MI and the impact of simulated interventions were calculated utilizing the Data Collection on Adverse Effects of Anti-HIV Drugs Study (D:A:D) algorithm. Results: Smoking status data were collected from 4274 participants and 1496 of these had sufficient data for simulated intervention calculations. Current smoking prevalence in these two groups was similar (23.2% vs. 19.9%, respectively). Characteristics associated with current smoking included age > 50 years compared with 30–39 years [odds ratio (OR) 0.65; 95% confidence interval (CI) 0.51–0.83], HIV exposure through injecting drug use compared with heterosexual exposure (OR 3.03; 95% CI 2.25–4.07), and receiving antiretroviral therapy (ART) at study sites in Singapore, South Korea, Malaysia, Japan and Vietnam in comparison to Thailand (all OR > 2). Women were less likely to smoke than men (OR 0.11; 95% CI 0.08–0.14). In simulated interventions, smoking cessation demonstrated the greatest impact in reducing CVD and CHD risk and closely approximated the impact of switching from abacavir to an alternate antiretroviral in the reduction of 5-year MI risk. Conclusions: Multiple interventions could reduce CVD, CHD and MI risk in Asian HIV-positive patients, with smoking cessation potentially being the most influential.
ISSN: 14681293
Appears in Collections:Scopus 2016-2017

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