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http://repository.li.mahidol.ac.th/dspace/handle/123456789/41309| Title: | Depsidones and an α-pyrone derivative from Simpilcillium sp. PSU-H41, an endophytic fungus from Hevea brasiliensis leaf |
| Authors: | Praphatsorn Saetang Vatcharin Rukachaisirikul Souwalak Phongpaichit Sita Preedanon Jariya Sakayaroj Suparerk Borwornpinyo Sawinee Seemakhan Chatchai Muanprasat Prince of Songkla University Thailand National Center for Genetic Engineering and Biotechnology Mahidol University |
| Keywords: | Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology |
| Issue Date: | 1-Nov-2017 |
| Citation: | Phytochemistry. Vol.143, (2017), 115-123 |
| Abstract: | © 2017 Elsevier Ltd Nine previously undescribed depsidones (simplicildones A-I) and one previously undescribed α-pyrone (simplicilopyrone) were isolated from the endophytic fungus Simplicillium sp. PSU-H41 along with 11 known compounds. Their structures were established by extensive spectroscopic analysis. Simplicildone A and known botryorhodine C displayed weak antibacterial against Staphylococcus aureus with equal MIC values of 32 μg/mL. Additionally, botryorhodine C was active against methicillin-resistant S. aureus with the same MIC value. Simplicildone C exhibited weak antifungal activity against Cryptococcus neoformans with an MIC value of 32 μg/mL. In addition, simplicildones A and C and botryorhodine C were noncytotoxic against noncancerous Vero cells. |
| URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026908528&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/41309 |
| ISSN: | 00319422 |
| Appears in Collections: | Scopus 2016-2017 |
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