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Title: Depsidones and an α-pyrone derivative from Simpilcillium sp. PSU-H41, an endophytic fungus from Hevea brasiliensis leaf
Authors: Praphatsorn Saetang
Vatcharin Rukachaisirikul
Souwalak Phongpaichit
Sita Preedanon
Jariya Sakayaroj
Suparerk Borwornpinyo
Sawinee Seemakhan
Chatchai Muanprasat
Prince of Songkla University
Thailand National Center for Genetic Engineering and Biotechnology
Mahidol University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Nov-2017
Citation: Phytochemistry. Vol.143, (2017), 115-123
Abstract: © 2017 Elsevier Ltd Nine previously undescribed depsidones (simplicildones A-I) and one previously undescribed α-pyrone (simplicilopyrone) were isolated from the endophytic fungus Simplicillium sp. PSU-H41 along with 11 known compounds. Their structures were established by extensive spectroscopic analysis. Simplicildone A and known botryorhodine C displayed weak antibacterial against Staphylococcus aureus with equal MIC values of 32 μg/mL. Additionally, botryorhodine C was active against methicillin-resistant S. aureus with the same MIC value. Simplicildone C exhibited weak antifungal activity against Cryptococcus neoformans with an MIC value of 32 μg/mL. In addition, simplicildones A and C and botryorhodine C were noncytotoxic against noncancerous Vero cells.
ISSN: 00319422
Appears in Collections:Scopus 2016-2017

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