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Title: Calcium and vitamin D supplementation for prevention of preeclampsia: A systematic review and network meta-analysis
Authors: Win Khaing
Sakda Arj Ong Vallibhakara
Visasiri Tantrakul
Orawin Vallibhakara
Sasivimol Rattanasiri
Mark McEvoy
John Attia
Ammarin Thakkinstian
Mahidol University
University of Medicine
University of Newcastle Faculty of Medicine and Health Sciences
Keywords: Agricultural and Biological Sciences
Issue Date: 18-Oct-2017
Citation: Nutrients. Vol.9, No.10 (2017)
Abstract: © 2017 by the authors. Licensee MDPI, Basel, Switzerland. Vitamin D supplementation effects with or without calcium in pregnancy for reducing risk of preeclampsia and gestational or pregnancy induced hypertension are controversial. Literature was systematically searched in Medline, Scopus and Cochrane databases from inception to July 2017. Only randomized controlled trials (RCTs) in English were selected if they had any pair of interventions (calcium, vitamin D, both, or placebo). Systematic review with two-step network-meta-analysis was used to indirectly estimate supplementary effects. Twenty-seven RCTs with 28,000 women were eligible. A direct meta-analysis suggested that calcium, vitamin D, and calcium plus vitamin D could lower risk of preeclampsia when compared to placebo with the pooled risk ratios (RRs) of 0.54 (0.41, 0.70), 0.47 (0.24, 0.89) and 0.50 (0.32, 0.78), respectively. Results of network meta-analysis were similar with the corresponding RRs of 0.49 (0.35, 0.69), 0.43 (0.17, 1.11), and 0.57 (0.30, 1.10), respectively. None of the controls were significant. Efficacy of supplementation, which was ranked by surface under cumulative ranking probabilities, were: vitamin D (47.4%), calcium (31.6%) and calcium plus vitamin D (19.6%), respectively. Calcium supplementation may be used for prevention for preeclampsia. Vitamin D might also worked well but further large scale RCTs are warranted to confirm our findings.
ISSN: 20726643
Appears in Collections:Scopus 2016-2017

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