Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/41351
Title: P. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmission
Authors: Alistair R.D. McLean
Danielle Stanisic
Rose McGready
Kesinee Chotivanich
Caroline Clapham
Francesca Baiwog
Mupawjay Pimanpanarak
Peter Siba
Ivo Mueller
Christopher L. King
François Nosten
James G. Beeson
Stephen Rogerson
Julie A. Simpson
Freya J.I. Fowkes
Burnet Institute
University of Melbourne
Myanmar Oxford Clinical Research Unit
Griffith University
Mahidol University
Nuffield Department of Clinical Medicine
Papua New Guinea Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Institut Pasteur, Paris
Case Western Reserve University
Monash University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Oct-2017
Citation: PLoS ONE. Vol.12, No.10 (2017)
Abstract: © 2017 McLean et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Introduction: During pregnancy, immunoglobulin G (IgG) is transferred from the mother to the fetus, providing protection from disease in early infancy. Plasmodium falciparum infections may reduce maternofetal antibody transfer efficiency, but mechanisms remain unclear. Methods: Mother-cord paired serum samples collected at delivery from Papua New Guinea (PNG) and the Thailand-Myanmar Border Area (TMBA) were tested for IgG1 and IgG3 to four P. falciparum antigens and measles antigen, as well as total serum IgG. Multivariable linear regression was conducted to assess the association of peripheral P. falciparum infection during pregnancy or placental P. falciparum infection assessed at delivery with maternofetal antibody transfer efficiency. Path analysis assessed the extent to which associations between P. falciparum infection and antibody transfer were mediated by gestational age at delivery or levels of maternal total serum IgG. Results: Maternofetal antibody transfer efficiency of IgG1 and IgG3 was lower in PNG compared to TMBA (mean difference in cord antibody levels (controlling for maternal antibody levels) ranged from -0.88 to 0.09, median of -0.20 log2 units). Placental P. falciparum infections were associated with substantially lower maternofetal antibody transfer efficiency in PNG primigravid women (mean difference in cord antibody levels (controlling for maternal antibody levels) ranged from -0.62 to -0.10, median of -0.36 log2 units), but not multigravid women. The lower antibody transfer efficiency amongst primigravid women with placental infection was only partially mediated by gestational age at delivery (proportion indirect effect ranged from 0% to 18%), whereas no mediation effects of maternal total serum IgG were observed. Discussion: Primigravid women may be at risk of impaired maternofetal antibody transport with placental P. falciparum infection. Direct effects of P. falciparum on the placenta, rather than earlier gestational age and elevated serum IgG, are likely responsible for the majority of the reduction in maternofetal antibody transfer efficiency with placental infection.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85031302857&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/41351
ISSN: 19326203
Appears in Collections:Scopus 2016-2017

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.