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dc.contributor.authorAlistair R.D. McLeanen_US
dc.contributor.authorDanielle Stanisicen_US
dc.contributor.authorRose McGreadyen_US
dc.contributor.authorKesinee Chotivanichen_US
dc.contributor.authorCaroline Claphamen_US
dc.contributor.authorFrancesca Baiwogen_US
dc.contributor.authorMupawjay Pimanpanaraken_US
dc.contributor.authorPeter Sibaen_US
dc.contributor.authorIvo Muelleren_US
dc.contributor.authorChristopher L. Kingen_US
dc.contributor.authorFrançois Nostenen_US
dc.contributor.authorJames G. Beesonen_US
dc.contributor.authorStephen Rogersonen_US
dc.contributor.authorJulie A. Simpsonen_US
dc.contributor.authorFreya J.I. Fowkesen_US
dc.contributor.otherBurnet Instituteen_US
dc.contributor.otherUniversity of Melbourneen_US
dc.contributor.otherMyanmar Oxford Clinical Research Uniten_US
dc.contributor.otherGriffith Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherPapua New Guinea Institute of Medical Researchen_US
dc.contributor.otherWalter and Eliza Hall Institute of Medical Researchen_US
dc.contributor.otherInstitut Pasteur, Parisen_US
dc.contributor.otherCase Western Reserve Universityen_US
dc.contributor.otherMonash Universityen_US
dc.identifier.citationPLoS ONE. Vol.12, No.10 (2017)en_US
dc.description.abstract© 2017 McLean et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Introduction: During pregnancy, immunoglobulin G (IgG) is transferred from the mother to the fetus, providing protection from disease in early infancy. Plasmodium falciparum infections may reduce maternofetal antibody transfer efficiency, but mechanisms remain unclear. Methods: Mother-cord paired serum samples collected at delivery from Papua New Guinea (PNG) and the Thailand-Myanmar Border Area (TMBA) were tested for IgG1 and IgG3 to four P. falciparum antigens and measles antigen, as well as total serum IgG. Multivariable linear regression was conducted to assess the association of peripheral P. falciparum infection during pregnancy or placental P. falciparum infection assessed at delivery with maternofetal antibody transfer efficiency. Path analysis assessed the extent to which associations between P. falciparum infection and antibody transfer were mediated by gestational age at delivery or levels of maternal total serum IgG. Results: Maternofetal antibody transfer efficiency of IgG1 and IgG3 was lower in PNG compared to TMBA (mean difference in cord antibody levels (controlling for maternal antibody levels) ranged from -0.88 to 0.09, median of -0.20 log2 units). Placental P. falciparum infections were associated with substantially lower maternofetal antibody transfer efficiency in PNG primigravid women (mean difference in cord antibody levels (controlling for maternal antibody levels) ranged from -0.62 to -0.10, median of -0.36 log2 units), but not multigravid women. The lower antibody transfer efficiency amongst primigravid women with placental infection was only partially mediated by gestational age at delivery (proportion indirect effect ranged from 0% to 18%), whereas no mediation effects of maternal total serum IgG were observed. Discussion: Primigravid women may be at risk of impaired maternofetal antibody transport with placental P. falciparum infection. Direct effects of P. falciparum on the placenta, rather than earlier gestational age and elevated serum IgG, are likely responsible for the majority of the reduction in maternofetal antibody transfer efficiency with placental infection.en_US
dc.rightsMahidol Universityen_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleP. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmissionen_US
Appears in Collections:Scopus 2016-2017

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