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Title: The in vitro anthelmintic activity of the ethanol leaf extracts of Terminalia catappa L. On Fasciola gigantica
Authors: Panat Anuracpreeda
Runglawan Chawengkirttikul
Arin Ngamniyom
Busaba Panyarachun
Panupong Puttarak
Preeyaporn Koedrith
Noppadol Intaratat
Mahidol University
Srinakharinwirot University
Prince of Songkla University
Faculty of Environment and Resource Studies, Mahidol University
Keywords: Agricultural and Biological Sciences;Immunology and Microbiology
Issue Date: 1-Dec-2017
Citation: Parasitology. Vol.144, No.14 (2017), 1931-1942
Abstract: © Cambridge University Press 2017. At present, there are no medicinal plant extracts currently available for treatment and control of fasciolosis. The present work could provide, for the first study, conclusions on the in vitro fasciolicidal properties of the ethanol extract of Terminalia catappa L. (TcCE) leaves against adult Fasciola gigantica after incubation with RPMI-1640 medium containing the TcCE at various concentrations and times when compared with triclabendazole (TCZ). The relative motility and survival index values of the TcCE-treated flukes decreased at a more rapid rate than the TCZ-treated flukes. The death of the parasites was observed after exposed to TcCE at 3 h incubation with 400, 800 and 1000 μg mL-1, and at 6 h incubation in 100 and 200 μg mL-1. Vacuolization, blebbings and partial disruption on the parasites' tegument were observed by light microscopy. When examined by scanning electron microscopy, TcCE caused similar tegumental alterations in the parasites as those observed in TCZ treatment but with larger damage at comparative incubation periods, consisting of swelling, blebbing, disrupted blebs, loss of spines, leading to the erosion, lesion and eventual disruption of the total tegument. Therefore, the TcCE may exert its fasciolicidal effect against F. gigantica by initially causing the tegumental alteration.
ISSN: 14698161
Appears in Collections:Scopus 2016-2017

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