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Title: Parasites and asthma
Authors: Lin Wuhao
Chen Ran
He Xujin
Wu Zhongdao
Paron Dekumyoy
Lv Zhiyue
Sun Yat-Sen University, Zhongshan School of Medicine
Sun Yat-Sen University
South China Normal University
Provincial Engineering Technology Research Center for Biological Vector Control
Mahidol University
Keywords: Agricultural and Biological Sciences;Immunology and Microbiology
Issue Date: 1-Sep-2017
Citation: Parasitology Research. Vol.116, No.9 (2017), 2373-2383
Abstract: © 2017, Springer-Verlag GmbH Germany. Nowadays, many studies have found low morbidity of asthma in epidemic areas of parasitic diseases, as shown by the hygiene hypothesis. It is obvious that some parasite infections can prevent asthma and studies have been carried out to clarify the mechanism of the preventive effect and search for the future asthmatic therapies. Previous findings have indicated that this mechanism may be related to the immune response switching from Th1 to Th2 and important cells induced by parasites, including the regulatory T cells, regulatory B cells, dendrite cells, and alternatively activated macrophages. Cytokine IL-10 also plays a nonredundant role in protection against allergic airway inflammation in asthma. This review focuses on the relationship between parasites and asthma, and the potential protection mechanism involved.
ISSN: 14321955
Appears in Collections:Scopus 2016-2017

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