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dc.contributor.authorIzumi Mashimaen_US
dc.contributor.authorCitra F. Theodoreaen_US
dc.contributor.authorBoonyanit Thaweboonen_US
dc.contributor.authorSroisiri Thaweboonen_US
dc.contributor.authorFrank A. Scannapiecoen_US
dc.contributor.authorFutoshi Nakazawaen_US
dc.contributor.otherJapan Society for the Promotion of Scienceen_US
dc.contributor.otherUniversity at Buffalo, State University of New Yorken_US
dc.contributor.otherHealth Sciences University of Hokkaidoen_US
dc.contributor.otherUniversitas Indonesiaen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationPLoS ONE. Vol.12, No.9 (2017)en_US
dc.description.abstract© 2017 Mashima et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Poor oral hygiene often leads to chronic diseases such as periodontitis and dental caries resulting in substantial economic costs and diminished quality of life in not only adults but also in children. In this study, the salivary microbiome was characterized in a group of children stratified by the Simplified Oral Hygiene Index (OHI-S). Illumina MiSeq high-throughput sequencing based on the 16S rRNA was utilized to analyze 90 salivary samples (24 Good, 31 Moderate and 35 Poor oral hygiene) from a cohort of Thai children. A total of 38,521 OTUs (Operational Taxonomic Units) with a 97% similarity were characterized in all of the salivary samples. Twenty taxonomic groups (Seventeen genera, two families and one class; Streptococcus, Veillonella, Gemellaceae, Prevotella, Rothia, Porphyromonas, Granulicatella, Actinomyces, TM-7-3, Lepto-trichia, Haemophilus, Selenomonas, Neisseria, Megasphaera, Capnocytophaga, Oribacterium, Abiotrophia, Lachnospiraceae, Peptostreptococcus, and Atopobium) were found in all subjects and constituted 94.5–96.5% of the microbiome. Of these twenty genera, the proportion of Streptococcus decreased while Veillonella increased with poor oral hygiene status (P < 0.05). Furthermore, an unassigned species of Veillonella, Veillonella dispar and Veillonella parvula tended to be elevated in the Poor oral hygiene group. This is the first study demonstrating an important association between increase of Veillonella and poor oral hygiene status in children. However, further studies are required to identify the majority of Veillonella at species level in salivary microbiome of the Poor oral hygiene group.en_US
dc.rightsMahidol Universityen_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleExploring the salivary microbiome of children stratified by the oral hygiene indexen_US
Appears in Collections:Scopus 2016-2017

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