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Title: Selective Estrogen Receptor Modulator (SERM)-like Activities of Diarylheptanoid, a Phytoestrogen from Curcuma comosa, in Breast Cancer Cells, Pre-osteoblast Cells, and Rat Uterine Tissues
Authors: Natthakan Thongon
Nittaya Boonmuen
Kanoknetr Suksen
Patsorn Wichit
Arthit Chairoungdua
Patoomratana Tuchinda
Apichart Suksamrarn
Wipawee Winuthayanon
Pawinee Piyachaturawat
Mahidol University
Ramkhamhaeng University
Washington State University Pullman
Keywords: Agricultural and Biological Sciences;Chemistry
Issue Date: 3-May-2017
Citation: Journal of Agricultural and Food Chemistry. Vol.65, No.17 (2017), 3490-3496
Abstract: © 2017 American Chemical Society. Diarylheptanoids from Curcuma comosa, of the Zingiberaceae family, exhibit diverse estrogenic activities. In this study we investigated the estrogenic activity of a major hydroxyl diarylheptanoid, 7-(3,4 -dihydroxyphenyl)-5-hydroxy-1-phenyl-(1E)-1-heptene (compound 092) isolated from C. comosa. The compound elicited different transcriptional activities of estrogen agonist at low concentrations (0.1-1 μM) and antagonist at high concentrations (10-50 μM) using luciferase reporter gene assay in HEK-293T cells. In human breast cancer (MCF-7) cells, compound 092 showed an anti-estrogenic activity by down-regulating ERα-signaling and suppressing estrogen-responsive genes, whereas it attenuated the uterotrophic effect of estrogen in immature ovariectomized rats. Of note, compound 092 promoted mouse pre-osteoblastic (MC3T3-E1) cell differentiation and the related bone markers, indicating its positive osteogenic effect. Our findings highlight a new, nonsteroidal, estrogen agonist/antagonist of catechol diarylheptanoid from C. comosa, which is scientific evidence supporting its potential as a dietary supplement to prevent bone loss with low risk of breast and uterine cancers in postmenopausal women.
ISSN: 15205118
Appears in Collections:Scopus 2016-2017

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