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Title: Variable number of tandem repeats of 9 Plasmodium vivax genes among Southeast Asian isolates
Authors: Bo Wang
Myat Htut Nyunt
Seung Gyu Yun
Feng Lu
Yang Cheng
Jin Hee Han
Kwon Soo Ha
Won Sun Park
Seok Ho Hong
Chae Seung Lim
Jun Cao
Jetsumon Sattabongkot
Myat Phone Kyaw
Liwang Cui
Eun Taek Han
Kangwon National University
Anhui Medical University
Department of Medical Research
Korea University
Jiangsu Institute of Parasitic Diseases
Jiangnan University
Mahidol University
Pennsylvania State University
Keywords: Agricultural and Biological Sciences;Immunology and Microbiology
Issue Date: 1-Jun-2017
Citation: Acta Tropica. Vol.170, (2017), 161-168
Abstract: © 2017 Elsevier B.V. The variable number of tandem repeats (VNTRs) provides valuable information about both the functional and evolutionary aspects of genetic diversity. Comparative analysis of 3 Plasmodium falciparum genomes has shown that more than 9% of its open reading frames (ORFs) harbor VNTRs. Although microsatellites and VNTR genes of P. vivax were reported, the VNTR polymorphism of genes has not been examined widely. In this study, 230 P. vivax genes were analyzed for VNTRs by SERV, and 33 kinds of TR deletions or insertions from 29 P. vivax genes (12.6%) were found. Of these, 9 VNTR fragments from 8 P. vivax genes were used for PCR amplification and sequence analysis to examine the genetic diversity among 134 isolates from four Southeast Asian countries (China, Republic of Korea, Thailand, and Myanmar) with different malaria endemicity. We confirmed the existence of extensive polymorphism of VNTR fragments in field isolates. This detection provides several suitable markers for analysis of the molecular epidemiology of P. vivax field isolates.
ISSN: 18736254
Appears in Collections:Scopus 2016-2017

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