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Title: Decay of the glycolytic pathway and adaptation to intranuclear parasitism within Enterocytozoonidae microsporidia
Authors: Dominic Wiredu Boakye
Pattana Jaroenlak
Anuphap Prachumwat
Tom A. Williams
Kelly S. Bateman
Ornchuma Itsathitphaisarn
Kallaya Sritunyalucksana
Konrad H. Paszkiewicz
Karen A. Moore
Grant D. Stentiford
Bryony A.P. Williams
University of Exeter
Mahidol University
Thailand National Center for Genetic Engineering and Biotechnology
University of Bristol
European Union
Keywords: Agricultural and Biological Sciences;Immunology and Microbiology
Issue Date: 1-May-2017
Citation: Environmental Microbiology. Vol.19, No.5 (2017), 2077-2089
Abstract: © 2017 Society for Applied Microbiology and John Wiley & Sons Ltd Glycolysis and oxidative phosphorylation are the fundamental pathways of ATP generation in eukaryotes. Yet in microsporidia, endoparasitic fungi living at the limits of cellular streamlining, oxidative phosphorylation has been lost: energy is obtained directly from the host or, during the dispersive spore stage, via glycolysis. It was therefore surprising when the first sequenced genome from the Enterocytozoonidae – a major family of human and animal-infecting microsporidians – appeared to have lost genes for glycolysis. Here, we sequence and analyse genomes from additional members of this family, shedding new light on their unusual biology. Our survey includes the genome of Enterocytozoon hepatopenaei, a major aquacultural parasite currently causing substantial economic losses in shrimp farming, and Enterospora canceri, a pathogen that lives exclusively inside epithelial cell nuclei of its crab host. Our analysis of gene content across the clade suggests that Ent. canceri's adaptation to intranuclear life is underpinned by the expansion of transporter families. We demonstrate that this entire lineage of pathogens has lost glycolysis and, uniquely amongst eukaryotes, lacks any obvious intrinsic means of generating energy. Our study provides an important resource for the investigation of host-pathogen interactions and reductive evolution in one of the most medically and economically important microsporidian lineages.
ISSN: 14622920
Appears in Collections:Scopus 2016-2017

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