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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/41507
Title: Cytotoxic, anti-HIV–1 and anti-inflammatory activities of lanostanes from fruits of Garcinia speciosa
Authors: Phanruethai Pailee
Thongchai Kruahong
Sakchai Hongthong
Chutima Kuhakarn
Thaworn Jaipetch
Manat Pohmakotr
Surawat Jariyawat
Kanoknetr Suksen
Radeekorn Akkarawongsapat
Jitra Limthongkul
Ampai Panthong
Palangpon Kongsaeree
Samran Prabpai
Patoomratana Tuchinda
Vichai Reutrakul
Mahidol University
Rajabhat University
Chiang Mai University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jun-2017
Citation: Phytochemistry Letters. Vol.20, (2017), 111-118
Abstract: © 2017 Phytochemical Society of Europe Bioassays-guided isolation of the hexanes and ethyl acetate extracts of the fruits of Garcinia speciosa led to the isolation of three new lanostane triterpenes 1–3 together with three related known derivatives 4–6. The new structures elucidated on the basis of spectroscopic and X-ray diffraction techniques were identified to be methyl (22E,24E)-9α-hydroxy-3-oxolanosta-22,24-dien-26-oate (1), (22E,24E)-9α,11β-dihydroxy-3-oxolanosta-22,24-dien-26-oic acid (2), and (24E)-23-acetoxy-3-oxolanosta-9,24-dien-26-oic acid (3), namely garciosaterpenes D, E and F, respectively. All compounds were evaluated for their cytotoxic and anti-inflammatory activities along with anti-HIV–1 activity. Most of the compounds were found inactive in the cytotoxic assay except for compound 6 which exhibited selective cytotoxicity against a KB cell line. All compounds showed significant inhibitory activities against HIV–1 reverse transcriptase (RT) assay and in the syncytium inhibition assay. Compounds 1, 5 and 6 displayed promising inhibitory activity in anti-inflammatory process.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85018839417&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/41507
ISSN: 18767486
18743900
Appears in Collections:Scopus 2016-2017

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