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Title: Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa
Authors: Isaraporn Polbuppha
Wisanu Maneerat
Tawanun Sripisut
Thunwadee Limtharakul
Sarot Cheenpracha
Stephen G. Pyne
Chatchai Muanprasat
Sawinee Seemakhan
Suparerk Borwornpinyo
Surat Laphookhieo
Mae Fah Luang University
Chiang Mai University
University of Phayao
University of Wollongong
Mahidol University
Keywords: Agricultural and Biological Sciences
Issue Date: 1-Jan-2017
Citation: Natural Product Communications. Vol.12, No.7 (2017), 1073-1076
Abstract: The first phytochemical investigation of the twig extracts of Maclura fruticosa led to the isolation and identification of a new xanthone, maclurafruticosone (1), together with 14 known compounds (2-15). All compounds were elucidated using spectroscopic methods as well as through comparisons made with data reported in the literature. Some isolated compounds were evaluated for their antioxidant, α-glucosidase inhibitory and cytotoxic activities. Compound 4, 6 and 7 showed significant antioxidant activity against DPPH radicals with IC50values ranging from 7.45-V16.12 μM. Compound 4 also exhibited potent activity against ABTS.,h+scavenging activity with an IC50value of 0.55 iÓ 0.01 £gM which was better than positive control (ascorbic acid, IC502.35-0.17 μM). Compound 12 showed significant α-glucosidase inhibitory activity with an IC50value of 0.02-0.37 mM. Compounds 5, 6 and 12 showed weak cytotoxic activities against a colon cancer cell line with IC50values ranging from 22.35-47.62 μM.
ISSN: 15559475
Appears in Collections:Scopus 2016-2017

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