Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMarielle Tamigney Kenfacken_US
dc.contributor.authorMarcelina Mazuren_US
dc.contributor.authorTeerapat Nualnoien_US
dc.contributor.authorTeresa L. Shafferen_US
dc.contributor.authorAbba Ngassimouen_US
dc.contributor.authorYves Blérioten_US
dc.contributor.authorJérôme Marroten_US
dc.contributor.authorRoberta Marchettien_US
dc.contributor.authorKitisak Sintiprungraten_US
dc.contributor.authorNarisara Chantratitaen_US
dc.contributor.authorAlba Silipoen_US
dc.contributor.authorAntonio Molinaroen_US
dc.contributor.authorDavid P. AuCoinen_US
dc.contributor.authorMary N. Burtnicken_US
dc.contributor.authorPaul J. Bretten_US
dc.contributor.authorCharles Gauthieren_US
dc.contributor.otherUniversite de Poitiersen_US
dc.contributor.otherUniwersytet Przyrodniczy we Wroclawiuen_US
dc.contributor.otherUniversity of Nevada School of Medicineen_US
dc.contributor.otherPrince of Songkla Universityen_US
dc.contributor.otherUniversity of South Alabamaen_US
dc.contributor.otherInstitut Lavoisier de Versaillesen_US
dc.contributor.otherUniversità degli Studi di Napoli Federico IIen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherINRS-Institut Armand Frappieren_US
dc.identifier.citationNature Communications. Vol.8, No.1 (2017)en_US
dc.description.abstract© 2017 The Author(s). Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm), the etiologic agents of melioidosis and glanders, respectively, cause severe disease in both humans and animals. Studies have highlighted the importance of Bp and Bm lipopolysaccharides (LPS) as vaccine candidates. Here we describe the synthesis of seven oligosaccharides as the minimal structures featuring all of the reported acetylation/methylation patterns associated with Bp and Bm LPS O-antigens (OAgs). Our approach is based on the conversion of an l-rhamnose into a 6-deoxy-l-talose residue at a late stage of the synthetic sequence. Using biochemical and biophysical methods, we demonstrate the binding of several Bp and Bm LPS-specific monoclonal antibodies with terminal OAg residues. Mice immunized with terminal disaccharide-CRM197 constructs produced high-titer antibody responses that crossreacted with Bm-like OAgs. Collectively, these studies serve as foundation for the development of novel therapeutics, diagnostics, and vaccine candidates to combat diseases caused by Bp and Bm.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleDeciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigensen_US
Appears in Collections:Scopus 2016-2017

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.