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Title: Association of Helicobacter pylori with the Risk of Hepatic Encephalopathy
Authors: Karn Wijarnpreecha
Supavit Chesdachai
Charat Thongprayoon
Veeravich Jaruvongvanich
Patompong Ungprasert
Wisit Cheungpasitporn
Bassett Medical Center
Mahidol University
University of Hawaii at Manoa
Mayo Clinic
University of Mississippi Medical Center
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Dec-2017
Citation: Digestive Diseases and Sciences. Vol.62, No.12 (2017), 3614-3621
Abstract: © 2017, Springer Science+Business Media, LLC, part of Springer Nature. Background/Objectives: Hepatic encephalopathy is the common manifestation of decompensated cirrhosis. The association between Helicobacter pylori (H. pylori) infection and hepatic encephalopathy has been shown in many epidemiologic studies. This meta-analysis was conducted to summarize all available studies to estimate the association between H. pylori infection and hepatic encephalopathy. Methods: A comprehensive literature review was conducted using MEDLINE and EMBASE database through March 2017 to identify studies that reported the association between H. pylori infection and hepatic encephalopathy. Effect estimates from the individual study were extracted and combined using random-effect, generic inverse variance method of DerSimonian and Laird. Results: Of 15,233 studies, eleven studies (four cross-sectional, four case–control, and three cohort studies) met the eligibility criteria and were included in the meta-analysis. The pooled OR of hepatic encephalopathy in patients with H. pylori infection was 1.73 (95% CI 1.09–2.73) when compared with the patients without H. pylori infection. The association between H. pylori and hepatic encephalopathy was not statistically significant after the sensitivity analysis, excluding those using ELISA alone, with a pooled OR of 1.92 (95% CI 0.91–4.05, I2 = 62%). There was no publication bias of overall included studies assessed by the funnel plots and Egger’s regression asymmetry test. Conclusions: This study demonstrated a potential association between H. pylori infection and risk of hepatic encephalopathy. Future studies are required to assess the effect of chronicity of infection on the development of hepatic encephalopathy.
ISSN: 15732568
Appears in Collections:Scopus 2016-2017

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