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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/41711
Title: Enhanced transmucosal delivery of itraconazole by thiolated D-ɑ-tocopheryl poly(ethylene glycol) 1000 succinate micelles for the treatment of Candida albicans
Authors: Jiraphong Suksiriworapong
Thawanrat Mingkwan
Doungdaw Chantasart
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Nov-2017
Citation: European Journal of Pharmaceutics and Biopharmaceutics. Vol.120, (2017), 107-115
Abstract: © 2017 Elsevier B.V. This study aimed to investigate the transmucosal delivery of itraconazole (ITZ) by thiolated D-ɑ-tocopheryl poly(ethylene glycol) 1000 succinate (TPGS-Cys) micelles. TPGS-Cys polymer was successfully synthesized by the simple coupling between carboxyl-activated TPGS and Cys as confirmed by NMR and FTIR techniques. Afterwards, the TPGS/TPGS-Cys micelles were prepared using the blend of TPGS and TPGS-Cys at 10:0, 7:3, 5:5, 3:7 and 0:10 mass ratios. All micelles had the size ranged from 8 to 10 nm with narrow size distribution and showed spherical in shape. The surface of the 10:0 TPGS micelles exhibited negatively charge while, the TPGS-Cys micelles demonstrated the slightly positive surface charge. The critical micelle concentration, loading capacity and release profiles of TPGS/TPGS-Cys micelles were comparable to the TPGS micelles. The release of ITZ from all micelles was biphasic and sustained in simulated saliva fluid over 48 h. The 3:7 and 0:10 TPGS/TPGS-Cys micelles had a good mucoadhesive property. Meanwhile, only 0:10 TPGS/TPGS-Cys micelles enhanced the permeability through buccal mucosa and potentiated the antifungal activity of ITZ against Candida albicans by at least 1.35 folds as compared to ITZ alone. Therefore, this formulation can be further developed for the transmucosal delivery of ITZ for the treatment of C. albicans.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85028869674&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/41711
ISSN: 18733441
09396411
Appears in Collections:Scopus 2016-2017

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