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|Title:||9-vinylanthracene based fluorogens: Synthesis, structure-property relationships and applications|
Lewis Yi Fong Tan
Mohammad A. Haghighatbin
Tze Cin Owyong
Conor F. Hogan
Trevor A. Smith
La Trobe University
University of Melbourne
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry|
|Citation:||Molecules. Vol.22, No.12 (2017)|
|Abstract:||© 2017 by the authors. Fluorescent dyes with aggregation-induced emission (AIE) properties exhibit intensified emission upon aggregation. They are promising candidates to study biomolecules and cellular changes in aqueous environments when aggregation formation occurs. Here, we report a group of 9-position functionalized anthracene derivatives that were conveniently synthesized by the palladium-catalyzed Heck reaction. Using fluorometric analyses, these dyes were confirmed to show AIE behavior upon forming aggregates at high concentrations, in viscous solvents, and when poorly solubilized. Their photophysical properties were then further correlated with their structural features, using density functional theory (DFT) calculation. Finally, we demonstrated their potential applications in monitoring pH changes, quantifying globular proteins, as well as cell imaging with confocal microscopy.|
|Appears in Collections:||Scopus 2016-2017|
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