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Title: RUNX1 Regulates Migration, Invasion, and Angiogenesis via p38 MAPK Pathway in Human Glioblastoma
Authors: Kant Sangpairoj
Pornpun Vivithanaporn
Somjai Apisawetakan
Sukumal Chongthammakun
Prasert Sobhon
Kulathida Chaithirayanon
Mahidol University
Srinakharinwirot University
Burapha University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Oct-2017
Citation: Cellular and Molecular Neurobiology. Vol.37, No.7 (2017), 1243-1255
Abstract: © 2016, Springer Science+Business Media New York. Runt-related transcription factor 1 (RUNX1) is essential for the establishment of fetal and adult hematopoiesis and neuronal development. Aberrant expression of RUNX1 led to proliferation and metastasis of several cancers. The aim of the present study was to investigate the role of RUNX1 in migration, invasion, and angiogenesis of human glioblastoma using IL-1β-treated U-87 MG human glioblastoma cells as a model. IL-1β at 10 ng/ml stimulated translocation of RUNX1 into the nucleus with increased expressions of RUNX1, MMP-1, MMP-2, MMP-9, MMP-19, and VEGFA in U-87 MG cells. In addition, silencing of RUNX1 gene significantly suppressed U-87 MG cell migration and invasion abilities. Moreover, knockdown of RUNX1 mRNA in U-87 MG cells reduced the tube formation of human umbilical vein endothelial cells. Further investigation revealed that IL-1β-induced RUNX1 expression might be mediated via the p38 mitogen-activated protein kinase (MAPK) signaling molecule for the expression of these invasion- and angiogenic-related molecules. Together with an inhibitor of p38 MAPK (SB203580) could decrease RUNX1 mRNA expression. Thus, RUNX1 may be one of the putative molecular targeted therapies against glioma metastasis and angiogenesis through the activation of p38 MAPK signaling pathway.
ISSN: 15736830
Appears in Collections:Scopus 2016-2017

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