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Title: The activation of B cells enhances DC-SIGN expression and promotes susceptibility of B cells to HPAI H5N1 infection
Authors: Prasit Na-Ek
Jutarat Thewsoongnoen
Maytawan Thanunchai
Suwimon Wiboon-Ut
Noppadol Sa-Ard-Iam
Rangsini Mahanonda
Arunee Thitithanyanont
Mahidol University
Vajira Hospital
Chulalongkorn University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 2-Sep-2017
Citation: Biochemical and Biophysical Research Communications. Vol.490, No.4 (2017), 1301-1306
Abstract: © 2017 Elsevier Inc. The interplay between highly pathogenic avian influenza (HPAI) H5N1 virus and immune cells has been extensively studied for years, as host immune components are thought to play significant roles in promoting the systemic spread of the virus and responsible for cytokine storm. Previous studies suggested that the interaction of B cells and monocytes could promote HPAI H5N1 infection by enhancing avian influenza virus receptor expression. In this study, we further investigate the relationship between the HPAI H5N1 virus, activated B cells, and DC-SIGN expression. DC-SIGN has been described as an important factor for mediating various types of viral infection. Here, we first demonstrate that HPAI H5N1 infection could induce an activation of B cells, which was associated with DC-SIGN expression. Using CD40L and recombinant IL-4 for B cell stimulation, we determined that DC-SIGN expressed on activated B cells was able to enhance its susceptibility to HPAI H5N1 infection. Our findings uncover the interplay between this H5N1 virus and B cells and provide important information in understanding how the virus overcomes our immune system, contributing to its unusual immunopathogenesis.
ISSN: 10902104
Appears in Collections:Scopus 2016-2017

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