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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/41804
Title: Insights into the naturally acquired immune response to Plasmodium vivax malaria
Authors: Rhea J. Longley
Jetsumon Sattabongkot
Ivo Mueller
Walter and Eliza Hall Institute of Medical Research
Mahidol University
University of Melbourne
Instituto de Salud Global de Barcelona
Keywords: Agricultural and Biological Sciences;Immunology and Microbiology
Issue Date: 1-Feb-2016
Citation: Parasitology. Vol.143, No.2 (2016), 154-170
Abstract: © Cambridge University Press 2016. Plasmodium vivax is the most geographically widespread of the malaria parasites causing human disease, yet it is comparatively understudied compared with Plasmodium falciparum. In this article we review what is known about naturally acquired immunity to P. Vivax, and importantly, how this differs to that acquired against P. Falciparum. Immunity to clinical P. Vivax infection is acquired more quickly than to P. Falciparum, and evidence suggests humans in endemic areas also have a greater capacity to mount a successful immunological memory response to this pathogen. Both of these factors give promise to the idea of a successful P. Vivax vaccine. We review what is known about both the cellular and humoral immune response, including the role of cytokines, antibodies, immunoregulation, immune memory and immune dysfunction. Furthermore, we discuss where the future lies in terms of advancing our understanding of naturally acquired immunity to P. Vivax, through the use of well-designed longitudinal epidemiological studies and modern tools available to immunologists.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84958673928&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/41804
ISSN: 14698161
00311820
Appears in Collections:Scopus 2016-2017

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