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Title: Strict tropism for CD71<sup>+</sup>/CD234<sup>+</sup> human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi
Authors: Varakorn Kosaisavee
Rossarin Suwanarusk
Adeline C.Y. Chua
Dennis E. Kyle
Benoit Malleret
Rou Zhang
Mallika Imwong
Rawiwan Imerbsin
Ratawan Ubalee
Hugo Sámano-Sánchez
Bryan K.S. Yeung
Jessica J.Y. Ong
Eric Lombardini
François Nosten
Kevin S.W. Tan
Pablo Bifani
Georges Snounou
Laurent Rénia
Bruce Russell
Mahidol University
Yong Loo Lin School of Medicine
A-Star, Singapore Immunology Network
University of Otago
University of South Florida Health
Armed Forces Research Institute of Medical Sciences, Thailand
Novartis Institute of Tropical Diseases
Nuffield Department of Clinical Medicine
Sorbonne Universite
CNRS Centre National de la Recherche Scientifique
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 14-Sep-2017
Citation: Blood. Vol.130, No.11 (2017), 1357-1363
Abstract: © 2017, American Society of Hematology. All rights reserved. Two malaria parasites of Southeast Asian macaques, Plasmodium knowlesi and P cynomolgi, can infect humans experimentally. In Malaysia, where both species are common, zoonotic knowlesi malaria has recently become dominant, and cases are recorded throughout the region. By contrast, to date, only a single case of naturally acquired P cynomolgi has been found in humans. In this study, we show that whereas P cynomolgi merozoites invade monkey red blood cells indiscriminately in vitro, in humans, they are restricted to reticulocytes expressing both transferrin receptor 1 (Trf1 or CD71) and the Duffy antigen/chemokine receptor (DARC or CD234). This likely contributes to the paucity of detectable zoonotic cynomolgi malaria. We further describe postinvasion morphologic and rheologic alterations in P cynomolgi–infected human reticulocytes that are strikingly similar to those observed for P vivax. These observations stress the value of P cynomolgi as a model in the development of blood stage vaccines against vivax malaria.
ISSN: 15280020
Appears in Collections:Scopus 2016-2017

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