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Title: In vitro assessment of Ag-TiO<inf>2</inf>/polyurethane nanocomposites for infection control using response surface methodology
Authors: Phasinee Khwanmuang
Porpon Rotjanapan
Angsana Phuphuakrat
Sirawat Srichatrapimuk
Chayanisa Chitichotpanya
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemical Engineering;Chemistry;Environmental Science
Issue Date: 1-Aug-2017
Citation: Reactive and Functional Polymers. Vol.117, (2017), 120-130
Abstract: © 2017 Elsevier B.V. Combining the use of a central composite design (CCD) with a response surface methodology (RSM), Ag-TiO2/Polyurethane (PU) nanocomposites with superior antimicrobial activities and minimal color changes were developed and optimized for self-disinfecting coating. An experimental design was utilized to assess the effects of two independent variables: 1) AgNO3content and 2) TiO2content on four measured responses, i.e., the reduction of E. coli and S. aureus, color differences, and the amount of Ag+release of nanocomposites. The nanocomposites were characterized by Transmission Electron Microscope, and X-ray diffraction. To validate the optimal conditions for real clinical applications for Ramathibodi Hospital (Bangkok, Thailand), the performance evaluations of the coatings such as cytotoxicity test and color differences were conducted, and the antibacterial activities were tested against seven key strains of antibiotic-resistant bacteria. The result suggested that this formulation has high potential for self-disinfecting coating applications.
ISSN: 13815148
Appears in Collections:Scopus 2016-2017

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