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Title: Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications
Authors: Peter W. Andrews
Uri Ben-David
Nissim Benvenisty
Peter Coffey
Kevin Eggan
Barbara B. Knowles
Andras Nagy
Martin Pera
Benjamin Reubinoff
Peter J. Rugg-Gunn
Glyn N. Stacey
University of Sheffield
Broad Institute
Hebrew University of Jerusalem
UCL Institute of Ophthalmology
University of California, Santa Barbara
Harvard University
Harvard Stem Cell Institute
Jackson Laboratory
Mahidol University
Mount Sinai Hospital of University of Toronto
Monash University
University of Melbourne
The Florey Institute of Neuroscience and Mental Health
Walter and Eliza Hall Institute of Medical Research
Hadassah University Medical Centre
The Babraham Institute
Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute
Medicines and Health Care products Regulatory Agency
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 11-Jul-2017
Citation: Stem Cell Reports. Vol.9, No.1 (2017), 1-4
Abstract: © 2017 Pluripotent stem cells may acquire genetic and epigenetic variants during culture following their derivation. At a conference organized by the International Stem Cell Initiative, and held at The Jackson Laboratory, Bar Harbor, Maine, October 2016, participants discussed how the appearance of such variants can be monitored and minimized and, crucially, how their significance for the safety of therapeutic applications of these cells can be assessed. A strong recommendation from the meeting was that an international advisory group should be set up to review the genetic and epigenetic changes observed in human pluripotent stem cell lines and establish a framework for evaluating the risks that they may pose for clinical use.
ISSN: 22136711
Appears in Collections:Scopus 2016-2017

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