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Title: Plasma prefractionation methods for proteomic analysis and perspectives in clinical applications
Authors: Somchai Chutipongtanate
Supawat Chatchen
Jisnuson Svasti
Mahidol University
Chulabhorn Research Institute
Chulabhorn Graduate Institute
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jul-2017
Citation: Proteomics - Clinical Applications. Vol.11, No.7-8 (2017)
Abstract: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Plasma is a rich source of biomarkers with clinical relevance. However, the wide dynamic range of protein concentration hinders the detection of low abundance proteins. Plasma prefractionation methods serve as indispensable tools to reduce plasma complexity, allowing the opportunity to explore tissue-derived proteins which leak into the circulation. This review summarizes common approaches in plasma prefractionation methods for proteomic analysis and then discusses some considerations in plasma prefractionation for clinical applications, reviewing some examples of its use in clinical situations.
ISSN: 18628354
Appears in Collections:Scopus 2016-2017

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