Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: Platelet inhibition and increased phosphorylated vasodilator-stimulated phosphoprotein following sodium nitrite inhalation
Authors: Tipparat Parakaw
Kran Suknuntha
Pornpun Vivithanaporn
Axel Schlagenhauf
Supachai Topanurak
Suthat Fucharoen
Kovit Pattanapanyasat
Alan Schechter
Nathawut Sibmooh
Sirada Srihirun
Mahidol University
Medizinische Universität Graz
National Institute of Diabetes and Digestive and Kidney Diseases
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jun-2017
Citation: Nitric Oxide - Biology and Chemistry. Vol.66, (2017), 10-16
Abstract: © 2017 Elsevier Inc. In the presence of red blood cells (RBCs), nitrite inhibits platelets through its conversion to nitric oxide (NO) by the reductase activity of partially deoxygenated hemoglobin. Inhaled sodium nitrite is being investigated as a therapy for pulmonary hypertension. Here, we measured platelet aggregation, P-selectin expression, platelet-leukocyte aggregates and phosphorylated vasodilator-stimulated phosphoprotein (P-VASPSer239) following sodium nitrite inhalation in healthy subjects. In vitro incubation of nitrite with deoxygenated whole blood showed an increase in P-VASPSer239, which was inhibited by ODQ, a soluble guanylyl cyclase (sGC) inhibitor. Immediately and 60 min after nitrite inhalation, P-VASPSer239 increased in platelets. Platelet aggregation, P-selectin expression, platelet-monocyte and platelet-lymphocyte aggregates decreased after inhalation. In conclusion, sodium nitrite administered to healthy subjects by inhalation can inhibit platelet activation and increase P-VASPSer239 in platelets. Platelet inhibition by nitrite administration may be useful in disorders associated with platelet hyperactivity.
ISSN: 10898611
Appears in Collections:Scopus 2016-2017

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.