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dc.contributor.authorTipparat Parakawen_US
dc.contributor.authorKran Suknunthaen_US
dc.contributor.authorPornpun Vivithanapornen_US
dc.contributor.authorAxel Schlagenhaufen_US
dc.contributor.authorSupachai Topanuraken_US
dc.contributor.authorSuthat Fucharoenen_US
dc.contributor.authorKovit Pattanapanyasaten_US
dc.contributor.authorAlan Schechteren_US
dc.contributor.authorNathawut Sibmoohen_US
dc.contributor.authorSirada Srihirunen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherMedizinische Universität Grazen_US
dc.contributor.otherNational Institute of Diabetes and Digestive and Kidney Diseasesen_US
dc.identifier.citationNitric Oxide - Biology and Chemistry. Vol.66, (2017), 10-16en_US
dc.description.abstract© 2017 Elsevier Inc. In the presence of red blood cells (RBCs), nitrite inhibits platelets through its conversion to nitric oxide (NO) by the reductase activity of partially deoxygenated hemoglobin. Inhaled sodium nitrite is being investigated as a therapy for pulmonary hypertension. Here, we measured platelet aggregation, P-selectin expression, platelet-leukocyte aggregates and phosphorylated vasodilator-stimulated phosphoprotein (P-VASPSer239) following sodium nitrite inhalation in healthy subjects. In vitro incubation of nitrite with deoxygenated whole blood showed an increase in P-VASPSer239, which was inhibited by ODQ, a soluble guanylyl cyclase (sGC) inhibitor. Immediately and 60 min after nitrite inhalation, P-VASPSer239 increased in platelets. Platelet aggregation, P-selectin expression, platelet-monocyte and platelet-lymphocyte aggregates decreased after inhalation. In conclusion, sodium nitrite administered to healthy subjects by inhalation can inhibit platelet activation and increase P-VASPSer239 in platelets. Platelet inhibition by nitrite administration may be useful in disorders associated with platelet hyperactivity.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titlePlatelet inhibition and increased phosphorylated vasodilator-stimulated phosphoprotein following sodium nitrite inhalationen_US
Appears in Collections:Scopus 2016-2017

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