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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/41867
Title: Anti-inflammatory 12,20-Epoxypregnane and 11,12-seco-Pregnane Glycosides from the Stems of Hoya kerrii
Authors: Chonticha Seeka
Samran Prabpai
Palangpon Kongsaeree
Supinya Tewtrakul
Thitima Lhinhatrakool
Somyote Sutthivaiyakit
Ramkhamhaeng University
Mahidol University
Prince of Songkla University
Rangsit University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 23-Jun-2017
Citation: Journal of Natural Products. Vol.80, No.6 (2017), 1714-1724
Abstract: © 2017 The American Chemical Society and American Society of Pharmacognosy. Five 12,20-epoxypregnane glycosides (1-3, 5, and 6) and two 11,12-seco-pregnane glycosides (4 and 7) with spirodilactone motifs, as well as spirodilactone cleavage products 8 and 9, were isolated from the stems of Hoya kerrii. The relative configurations of the three related skeletons were supported by ROESY experiments and X-ray crystallographic analyses. The isolates were evaluated for their anti-inflammatory activity based on the inhibition of NO production in RAW264.7 cells, and some showed IC50values ranging from 12.6 to 96.5 μM. The most potent compound, 9a, was also examined for its anti-inflammatory mechanism against mRNA expression and was found to down-regulate mRNA expression of iNOS and COX-2 in a dose-dependent manner.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85021128411&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/41867
ISSN: 15206025
01633864
Appears in Collections:Scopus 2016-2017

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