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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/41876
Title: Establishment of MUi009 – A human induced pluripotent stem cells from a 32 year old male with homozygous β°-thalassemia coinherited with heterozygous α-thalassemia 2
Authors: Wasinee Wongkummool
Warun Maneepitasut
Pirut Tong-ngam
Amornrat Tangprasittipap
Thongperm Munkongdee
Chanikarn Boonchuay
Saovaros Svasti
Narisorn Kitiyanant
Kittiphong Paiboonsukwong
Suthat Fucharoen
Alisa Tubsuwan
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Apr-2017
Citation: Stem Cell Research. Vol.20, (2017), 80-83
Abstract: © 2017 The Authors The thalassemias are a group of genetic disorders characterized by a deficiency in the synthesis of globin chains. In this study the MUi009-A human induced pluripotent stem cell line was successfully generated from peripheral blood CD34 + haematopoietic progenitors of a 32 year old male who had coinherited a homozygous β°-thalassemia mutation at codon 41/42 (-TCTT) and a heterozygous α-thalassemia 4.2 deletion. The MUi009-A cell line exhibited embryonic stem cell characteristics with consistent pluripotency marker expression and the capability of differentiating into the three germ layers. The cell line may provide a tool for drug testing and gene therapy studies.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015405232&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/41876
ISSN: 18767753
18735061
Appears in Collections:Scopus 2016-2017

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