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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/41885
Title: Establishment of a rabbit induced pluripotent stem cell (RbiPSC) line using lentiviral delivery of human pluripotency factors
Authors: Zsuzsanna Táncos
Csilla Nemes
Eszter Varga
István Bock
Sasitorn Rungarunlert
Theerawat Tharasanit
Mongkol Techakumphu
Julianna Kobolák
András Dinnyés
Szent István Egyetem
BioTalentum Ltd.
Mahidol University
Chulalongkorn University
Utrecht University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-May-2017
Citation: Stem Cell Research. Vol.21, (2017), 16-18
Abstract: © 2017 The Authors Rabbit Embryonic Fibroblast (RbEF) cells (from Hycole hybrid rabbit foetus) were reprogrammed by lentiviral delivery of a self-silencing hOKSM polycistronic vector. The pluripotency of the newly generated RbiPSC was verified by the expression of pluripotency-associated markers and by in vitro spontaneous differentiation towards the 3 germ layers. Furthermore, the spontaneous differentiation potential of the iPSC was also tested in vivo by teratoma assay. The iPSC line showed normal karyotype. The advantages of using RbiPSC are the easy access to primary material and the possibility to study the efficacy and safety of the iPSC-based therapies on a non-rodent animal model.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015993999&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/41885
ISSN: 18767753
18735061
Appears in Collections:Scopus 2016-2017

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