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Title: Plasmodium P36 determines host cell receptor usage during sporozoite invasion
Authors: Giulia Manzoni
Carine Marinach
Selma Topçu
Sylvie Briquet
Morgane Grand
Matthieu Tolle
Marion Gransagne
Julien Lescar
Chiara Andolina
Jean François Franetich
Mirjam B. Zeisel
Thierry Huby
Eric Rubinstein
Georges Snounou
Dominique Mazier
François Nosten
Thomas F. Baumert
Olivier Silvie
Mahidol University
Nuffield Department of Clinical Medicine
Université de Strasbourg
Modeles de cellules souches malignes et therapeutiques
Institut Andre Lwoff
Hôpital Universitaire Pitié Salpêtrière
CHU Strasbourg
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 16-May-2017
Citation: eLife. Vol.6, (2017)
Abstract: © Manzoni et al. Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors.
ISSN: 2050084X
Appears in Collections:Scopus 2016-2017

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