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dc.contributor.authorGiulia Manzonien_US
dc.contributor.authorCarine Marinachen_US
dc.contributor.authorSelma Topçuen_US
dc.contributor.authorSylvie Briqueten_US
dc.contributor.authorMorgane Granden_US
dc.contributor.authorMatthieu Tolleen_US
dc.contributor.authorMarion Gransagneen_US
dc.contributor.authorJulien Lescaren_US
dc.contributor.authorChiara Andolinaen_US
dc.contributor.authorJean François Franetichen_US
dc.contributor.authorMirjam B. Zeiselen_US
dc.contributor.authorThierry Hubyen_US
dc.contributor.authorEric Rubinsteinen_US
dc.contributor.authorGeorges Snounouen_US
dc.contributor.authorDominique Mazieren_US
dc.contributor.authorFrançois Nostenen_US
dc.contributor.authorThomas F. Baumerten_US
dc.contributor.authorOlivier Silvieen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherUniversité de Strasbourgen_US
dc.contributor.otherModeles de cellules souches malignes et therapeutiquesen_US
dc.contributor.otherInstitut Andre Lwoffen_US
dc.contributor.otherHôpital Universitaire Pitié Salpêtrièreen_US
dc.contributor.otherCHU Strasbourgen_US
dc.identifier.citationeLife. Vol.6, (2017)en_US
dc.description.abstract© Manzoni et al. Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titlePlasmodium P36 determines host cell receptor usage during sporozoite invasionen_US
Appears in Collections:Scopus 2016-2017

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