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Title: Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa
Authors: Elin Näsström
Christopher M. Parry
Nga Tran Vu Thieu
Rapeephan R. Maude
Hanna K. de Jong
Masako Fukushima
Olena Rzhepishevska
Florian Marks
Ursula Panzner
Justin Im
Hyonjin Jeon
Seeun Park
Zabeen Chaudhury
Aniruddha Ghose
Rasheda Samad
Tan Trinh Van
Anders Johansson
Arjen M. Dondorp
Guy E. Thwaites
Abul Faiz
Henrik Antti
Stephen Baker
Umeå Universitet
Liverpool School of Tropical Medicine
Nagasaki University
University of Oxford
Oxford University Clinical Research Unit
Mahidol University
University of Amsterdam
Academic Medical Centre, University of Amsterdam
International Vaccine Institute, Seoul
Chittagong Medical College Hospital
Dev Care Foundation
University of Cambridge
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 9-May-2017
Citation: eLife. Vol.6, (2017)
Abstract: © Nasstrom et al. Salmonella Typhi is the causative agent of typhoid. Typhoid is diagnosed by blood culture, a method that lacks sensitivity, portability and speed. We have previously shown that specific metabolomic profiles can be detected in the blood of typhoid patients from Nepal (Nasstrom et al., 2014). Here, we performed mass spectrometry on plasma from Bangladeshi and Senegalese patients with culture confirmed typhoid fever, clinically suspected typhoid, and other febrile diseases including malaria. After applying supervised pattern recognition modelling, we could significantly distinguish metabolite profiles in plasma from the culture confirmed typhoid patients. After comparing the direction of change and degree of multivariate significance, we identified 24 metabolites that were consistently upor down regulated in a further Bangladeshi/Senegalese validation cohort, and the Nepali cohort from our previous work. We have identified and validated a metabolite panel that can distinguish typhoid from other febrile diseases, providing a new approach for typhoid diagnostics.
ISSN: 2050084X
Appears in Collections:Scopus 2016-2017

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