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Title: Scalemic Caged Xanthones Isolated from the Stem Bark Extract of Garcinia propinqua
Authors: Teerayut Sriyatep
Raymond J. Andersen
Brian O. Patrick
Stephen G. Pyne
Chatchai Muanprasat
Sawinee Seemakhan
Suparerk Borwornpinyo
Surat Laphookhieo
Mae Fah Luang University
The University of British Columbia
University of Wollongong
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 26-May-2017
Citation: Journal of Natural Products. Vol.80, No.5 (2017), 1658-1667
Abstract: © 2017 The American Chemical Society and American Society of Pharmacognosy. Seven new caged xanthones, doitunggarcinones E-K (1-7), all as scalemic mixtures and 10 known compounds (8-17), were isolated from the stem bark extract of Garcinia propinqua. The structures were elucidated on the basis of spectroscopic methods. The separation of the enantiomers of 1-6 was achieved by semipreparative chiral HPLC. The absolute configuration of compound (+)-1 was determined by single-crystal X-ray crystallographic analysis using Cu Kα radiation. The absolute configurations of the other related compounds were determined from comparisons of their ECD spectra with that of compound (+)-1. Compounds (-)-6 and 7 showed cytotoxicity against a colon cancer cell line with IC50 values of 14.23 and 23.95 μM, respectively.
ISSN: 15206025
Appears in Collections:Scopus 2016-2017

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