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Title: | Scalemic Caged Xanthones Isolated from the Stem Bark Extract of Garcinia propinqua |
Authors: | Teerayut Sriyatep Raymond J. Andersen Brian O. Patrick Stephen G. Pyne Chatchai Muanprasat Sawinee Seemakhan Suparerk Borwornpinyo Surat Laphookhieo Mae Fah Luang University The University of British Columbia University of Wollongong Mahidol University |
Keywords: | Biochemistry, Genetics and Molecular Biology;Chemistry |
Issue Date: | 26-May-2017 |
Citation: | Journal of Natural Products. Vol.80, No.5 (2017), 1658-1667 |
Abstract: | © 2017 The American Chemical Society and American Society of Pharmacognosy. Seven new caged xanthones, doitunggarcinones E-K (1-7), all as scalemic mixtures and 10 known compounds (8-17), were isolated from the stem bark extract of Garcinia propinqua. The structures were elucidated on the basis of spectroscopic methods. The separation of the enantiomers of 1-6 was achieved by semipreparative chiral HPLC. The absolute configuration of compound (+)-1 was determined by single-crystal X-ray crystallographic analysis using Cu Kα radiation. The absolute configurations of the other related compounds were determined from comparisons of their ECD spectra with that of compound (+)-1. Compounds (-)-6 and 7 showed cytotoxicity against a colon cancer cell line with IC50 values of 14.23 and 23.95 μM, respectively. |
URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85019729486&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/41925 |
ISSN: | 15206025 01633864 |
Appears in Collections: | Scopus 2016-2017 |
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