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|Title:||Scalemic Caged Xanthones Isolated from the Stem Bark Extract of Garcinia propinqua|
Raymond J. Andersen
Brian O. Patrick
Stephen G. Pyne
Mae Fah Luang University
The University of British Columbia
University of Wollongong
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry|
|Citation:||Journal of Natural Products. Vol.80, No.5 (2017), 1658-1667|
|Abstract:||© 2017 The American Chemical Society and American Society of Pharmacognosy. Seven new caged xanthones, doitunggarcinones E-K (1-7), all as scalemic mixtures and 10 known compounds (8-17), were isolated from the stem bark extract of Garcinia propinqua. The structures were elucidated on the basis of spectroscopic methods. The separation of the enantiomers of 1-6 was achieved by semipreparative chiral HPLC. The absolute configuration of compound (+)-1 was determined by single-crystal X-ray crystallographic analysis using Cu Kα radiation. The absolute configurations of the other related compounds were determined from comparisons of their ECD spectra with that of compound (+)-1. Compounds (-)-6 and 7 showed cytotoxicity against a colon cancer cell line with IC50 values of 14.23 and 23.95 μM, respectively.|
|Appears in Collections:||Scopus 2016-2017|
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