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Title: Derivation of the human induced pluripotent stem cell line MUi017-A from a patient with homozygous Hemoglobin Constant Spring
Authors: Wasinee Wongkummool
Warun Maneepitasut
Thongperm Munkongdee
Pirut Tong-ngam
Amornrat Tangprasittipap
Saovaros Svasti
Narisorn Kitiyanant
Kittiphong Paiboonsukwong
Suthat Fucharoen
Alisa Tubsuwan
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Apr-2017
Citation: Stem Cell Research. Vol.20, (2017), 84-87
Abstract: © 2017 The Authors Hemoglobin Constant Spring (HbCS, HBA2: c.427T > C) is a common nondeletional α-thalassemia resulting from a nucleotide substitution at the termination codon of the HBA2 gene. Homozygosity for HbCS is characterized with mild anemia, jaundice, and splenomegaly. In this study, the human induced pluripotent stem cell line MUi017-A was successfully generated from peripheral blood CD34 + hematopoietic progenitors of a 52 year old female with homozygous HbCS. The MUi017-A cell line exhibited embryonic stem cell characteristics with consistent expression of specific pluripotency markers and the capability of differentiating into the three germ layers. The cell line may be used for the disease modeling.
ISSN: 18767753
Appears in Collections:Scopus 2016-2017

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