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http://repository.li.mahidol.ac.th/dspace/handle/123456789/41931| Title: | Derivation of the human induced pluripotent stem cell line MUi017-A from a patient with homozygous Hemoglobin Constant Spring |
| Authors: | Wasinee Wongkummool Warun Maneepitasut Thongperm Munkongdee Pirut Tong-ngam Amornrat Tangprasittipap Saovaros Svasti Narisorn Kitiyanant Kittiphong Paiboonsukwong Suthat Fucharoen Alisa Tubsuwan Mahidol University |
| Keywords: | Biochemistry, Genetics and Molecular Biology |
| Issue Date: | 1-Apr-2017 |
| Citation: | Stem Cell Research. Vol.20, (2017), 84-87 |
| Abstract: | © 2017 The Authors Hemoglobin Constant Spring (HbCS, HBA2: c.427T > C) is a common nondeletional α-thalassemia resulting from a nucleotide substitution at the termination codon of the HBA2 gene. Homozygosity for HbCS is characterized with mild anemia, jaundice, and splenomegaly. In this study, the human induced pluripotent stem cell line MUi017-A was successfully generated from peripheral blood CD34 + hematopoietic progenitors of a 52 year old female with homozygous HbCS. The MUi017-A cell line exhibited embryonic stem cell characteristics with consistent expression of specific pluripotency markers and the capability of differentiating into the three germ layers. The cell line may be used for the disease modeling. |
| URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015675981&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/41931 |
| ISSN: | 18767753 18735061 |
| Appears in Collections: | Scopus 2016-2017 |
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