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Title: Characterising private and shared signatures of positive selection in 37 Asian populations
Authors: Xuanyao Liu
Dongsheng Lu
Woei Yuh Saw
Philip J. Shaw
Pongsakorn Wangkumhang
Chumpol Ngamphiw
Suthat Fucharoen
Worachart Lert-Itthiporn
Kwanrutai Chin-Inmanu
Tran Nguyen Bich Chau
Katie Anders
Anuradhani Kasturiratne
H. Janaka De Silva
Tomohiro Katsuya
Ryosuke Kimura
Toru Nabika
Takayoshi Ohkubo
Yasuharu Tabara
Fumihiko Takeuchi
Ken Yamamoto
Mitsuhiro Yokota
Dolikun Mamatyusupu
Wenjun Yang
Yeun Jun Chung
Li Jin
Boon Peng Hoh
Ananda R. Wickremasinghe
Ricktwee Hee Ong
Chiea Chuen Khor
Sarah J. Dunstan
Cameron Simmons
Sissades Tongsima
Prapat Suriyaphol
Norihiro Kato
Shuhua Xu
Yik Ying Teo
National University of Singapore
Shanghai Institute for Biological Sciences Chinese Academy of Sciences
Thailand National Center for Genetic Engineering and Biotechnology
Mahidol University
University of Oxford
Nuffield Department of Clinical Medicine
University of Kelaniya
Osaka University
University of the Ryukyus
Shimane University
Teikyo University
Kyoto University
National Center for Global Health and Medicine
Kurume University
Aichi Gakuin University
Xinjiang University
Ningxia Medical College
The Catholic University of Korea
Fudan University
UCSI University
A-Star, Genome Institute of Singapore
University of Melbourne
ShanghaiTech University
Collaborative Innovation Center of Genetics and Development
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Apr-2017
Citation: European Journal of Human Genetics. Vol.25, No.4 (2017), 499-508
Abstract: © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. The Asian Diversity Project (ADP) assembled 37 cosmopolitan and ethnic minority populations in Asia that have been densely genotyped across over half a million markers to study patterns of genetic diversity and positive natural selection. We performed population structure analyses of the ADP populations and divided these populations into four major groups based on their genographic information. By applying a highly sensitive algorithm haploPS to locate genomic signatures of positive selection, 140 distinct genomic regions exhibiting evidence of positive selection in at least one population were identified. We examined the extent of signal sharing for regions that were selected in multiple populations and observed that populations clustered in a similar fashion to that of how the ancestry clades were phylogenetically defined. In particular, populations predominantly located in South Asia underwent considerably different adaptation as compared with populations from the other geographical regions. Signatures of positive selection present in multiple geographical regions were predicted to be older and have emerged prior to the separation of the populations in the different regions. In contrast, selection signals present in a single population group tended to be of lower frequencies and thus can be attributed to recent evolutionary events.
ISSN: 14765438
Appears in Collections:Scopus 2016-2017

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